Gene has been married to Cynthia Searcy Jeffress for 44 years. They have three children, Terra, Geoff, and Justin, along with each of their spouses, and 5 grandchildren. Gene and Cynthia raised their children to be active in community activities, including 4-H, FFA, and church and school choirs. The Jeffress' are active church members, with Gene being a deacon and minister of music, and Cynthia singing in the choir. They enjoy spending time together for family meals, and they especially enjoy traveling and camping.
Gene is pro-life and believes in traditional, Conservative Arkansas family values. Gene has protected these values in the state legislature, and will continue to fight for them in the U.S. Congress.